DropBrigt® HEPES: The Multi-Tasking "Buffer-Plus" for Brighter, Smoother Skin

August 07, 2025

Unlock the hidden potential of formulations with DropBrigt^® HEPES (INCI: Hydroxyethylpiperazine Ethane Sulfonic Acid, CAS 7365-45-9)—a bio-compatible buffer that transcends pH control to deliver exfoliation, brightening, and UV-protective synergy. Backed by cutting-edge 3D skin models, here’s why this versatile active belongs in your next brightening or anti-aging formula.

🌟 Triple-Action Benefits

Gentle Exfoliation
- Weak acid (pH 4.5–6.5) with macromolecular AHA-like properties.
- Softens keratinocytes, smooths texture, and boosts cell turnover without irritation at recommended doses (0.5–5%).
Clinical Brightening Power
- Proven Synergy: In 3D melanin skin models, formulations with HEPES + tranexamic acid + AA2G + niacinamide (Composition A):
  - ↑ L* value (brightness) by 15% vs. controls (P<0.01)
  - ↓ Melanin content by 30% (P<0.01)
  - Outperformed fewer-actives combos (B/C) in reducing UV-induced pigmentation.
UV Absorption & Penetration Boost
- Absorbs UVA/visible light, offering secondary photoprotection.
- Enhances delivery of co-actives (e.g., vitamin C, niacinamide).

🔬 Science Spotlight: Brightening Synergy

Test Parameter	Composition A	Composition B	Composition C
Tranexamic Acid	3%	–	–
AA2G	1%	1%	–
Niacinamide	2%	5%	6%
HEPES	0.5%	0.5%	0.5%
Result vs. UV-Damaged Skin	↑ L* value 15% ↓ Melanin 30%	Moderate improvement	Minimal impact

Key Insight: HEPES amplifies brightening efficacy in multi-active systems—0.5% HEPES doubled melanin reduction vs. niacinamide-only formulas.

⚙️ Formulator-Friendly Profile

Solubility: Water-soluble (1M solution: clear, colorless).
Stability: Heat/light-stable; pH 4–8 compatible.
Addition: Flexible—cold or hot process (≤80°C).
Safety:
- Mild irritation (IS=4.77 at 2% in chicken embryo test).
- Optimal use: 0.5–2% in leave-on products.

✅ Premium Quality Standards

Parameter	Specification
Appearance	White crystalline powder
Purity (Assay)	≥99.5%
Heavy Metals	≤10 ppm (Pb ≤2 ppm)
Microbials	Complies with ISO 11930
Shelf Life	2 years (room temp, sealed)

💡 Why Choose DropBrigt^® HEPES?

Beyond buffering, this "smart" active:

Rescues UV-stressed skin via melanin suppression.
Boosts actives’ efficacy in serums, toners, and creams.
Works synergistically with brightening powerhouses (vitamin C, tranexamic acid).
Simplifies formulating with water solubility and process flexibility.

"HEPES isn’t just a pH adjuster—it’s a force multiplier for radiant skin results."

Elevate brightening formulations with DropBrigt^® HEPES—where science meets synergy.

If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

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