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Unlock Next-Level Hydration: Meet DropCare® PGA70 & PGA01 – Your Smart Molecular Weight Choice

Unlock Next-Level Hydration: Meet DropCare® PGA70 & PGA01 – Your Smart Molecular Weight Choice

June 05, 2025

The PGA Revolution: One Ingredient, Two Powerful Profiles

In the quest for breakthrough hydrators, Polyglutamic Acid (PGA) has emerged as a game-changer. But not all PGAs are created equal. At DropBio®, we engineered DropCare® PGA70 (700 kDa) and DropCare® PGA01 (10 kDa) to deliver targeted performance across all cosmetic formulations. Here’s why molecular weight matters:


The Science Behind PGA

Sodium Polyglutamate is a natural, fermentation-derived polymer with a unique γ-peptide bond structure (linking α-amino and γ-carboxyl groups). Its secret lies in:

  • 5000%+ water-binding capacity (outperforming hyaluronic acid)

  • Dense carboxyl side chains forming H-bond networks

  • Biofilm-forming ability that locks moisture into skin


Tailored Solutions: Molecular Weight Magic

Property DropCare® PGA70 (700 kDa) DropCare® PGA01 (10 kDa)
Primary Function Surface Film-Former Deep Skin Penetrator
Texture Velvety-thick Featherlight
Key Benefits • 24H barrier-locking hydration
• Wrinkle-smoothing film
• Enhances product spreadability
• Boosts NMF synthesis
• Transports actives deep into skin
• Instant plumping effect
Best For Creams/Masks/Leave-on products Serums/Toners/Rinse-off formulas

Proven Efficacy: Beyond Basic Moisturization

Both variants deliver multi-mechanistic anti-aging results:
✅ 3X Hyaluronic Acid Boost (in-vivo data)
✅ 28% Reduction in TEWL after 4 weeks
✅ 19% Improvement in skin elasticity
✅ Melanin Inhibition for brightening


Why Formulators Choose DropCare®

▶ PGA70 (700 kDa) – The Shield

  • Creates breathable moisture-trapping mesh

  • Perfect for high-viscosity anti-aging creams

  • Use at 0.5-1.0% for cushion-like texture

▶ PGA01 (10 kDa) – The Spear

  • Penetrates stratum corneum in <30 sec

  • Ideal for watery essences & boosters

  • Effective at 0.1-0.5% with zero tackiness

Application Genius

Pair them for synergistic effects:

  1. Cleanser: PGA01 (0.2%) → Preps skin for absorption

  2. Toner: PGA01 (0.3%) + PGA70 (0.1%) → Multi-depth hydration

  3. Cream: PGA70 (0.8%) → Seals in active ingredients

  • If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.
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